Agüero strikes for Manchester City before retiring with injury
Agüero, Yaya Toure, Edin Dzeko, Stevan Jovetic and Vincent Kompany were on target as City followed their 6-0 thrashing of Spurs in the reverse fixture with another thrilling exhibition of their attacking talents.
They were helped on their way by a controversial decision to send off Tottenham defender Danny Rose for a foul on Dzeko, for which City were awarded the penalty that Toure converted for the second goal.
Yet they ruthlessly exploited the extra man to move to 53 points, one clear of Arsenal and three ahead of Chelsea, who were frustrated by a fiercely resilient West Ham side at Stamford Bridge.
A muscle tear had previously kept El Kun out of action for a month, the former Independiente striker only returning to first-team duty on January 15.